Metabolomics, a subset of systems biology, is crucial for unraveling the complex metabolic pathways of Cucurbitales plants, specifically those in the Cucurbitales family. By utilizing the NPASS (Natural Products Activity and Species Source) database at https://bidd.group/NPASS/index.php, researchers can delve into the metabolomic profiles of Cucurbitales. This platform aids in identifying and characterizing metabolites, providing a comprehensive understanding of the distinctive metabolic mechanisms within the Cucurbitales kingdom. The NPASS database serves as a valuable resource for researchers exploring the metabolic intricacies of leguminous plants, contributing to our broader knowledge of plant metabolism.